The Reload button in Chrome has three options. If you open the Chrome DevTools (F12) the three options are visible by holding down the “Reload this page” button.

Normal Reload

Windows keyboard shortcut: F5 or CTRL + R

Reloads the current page.

Hard Reload

Windows keyboard shortcut: CTRL + Shift + R

Reloads the current page but ignoring the cached content.

Empty Cache and Hard Reload

Windows keyboard shortcut: Not available

This option empties the entire Browser cache and not just the parts for the current page. Given the impact of this option it makes sense that there is no keyboard shortcut which might accidentally trigger this option.

Acknowledgements

Scott Hanselman’s keynote at NDC London 2019 where he first made me (and half the hall if the sounds of “ooooo’s” is anything to go by) of this functionality in Chrome

This answer from Stack Overflow. Accessed 23/05/2019

This answer from Stack Overflow. Accessed 24/05/2019